SIRT5 Polyclonal AntibodyE-AB-12638
Product Type: Antibody
Descritpion: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: NP_001229756
Immunogen: Synthetic peptide of human SIRT5
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 22kDa
Tissue Specificity/Positive Control: Widely expressed.
Cellular Localization: Mitochondrion; Cytoplasm. Mitochondrion and Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-sirt5_polyclonal_antibody-32082.html
Manual Link: https://www.elabscience.com/viewpdf-32082-elabscience-E-AB-12638.PDF