Product Type: Antibody
Descritpion: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_003736
Immunogen: Synthetic peptide of human SOCS1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 24kDa
Tissue Specificity/Positive Control: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Cellular Localization: Cytosol,Nucleus,nucleoplasm,Other locations:cytoplasm,cytoplasmic ribonucleoprotein granule,cytoplasmic vesicle
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-socs1_polyclonal_antibody-32092.html
Manual Link: https://www.elabscience.com/viewpdf-32092-elabscience-E-AB-12648.PDF