Product Type: Antibody
Descritpion: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Research Areas: Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: NP_001245375
Immunogen: Synthetic peptide of human TOP1MT
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
Cellular Localization: Mitochondrion.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-top1mt_polyclonal_antibody-32107.html
Manual Link: https://www.elabscience.com/viewpdf-32107-elabscience-E-AB-12663.PDF