PRKG2 Polyclonal AntibodyE-AB-12751
Product Type: Antibody
Descritpion: cGKII (cGMP-dependent protein kinase type II) is a major receptor of intracellular cGMP and mediates a plethora of physiological responses. cGKII contains a conserved leucine zipper motif at the amino-terminus. It is expressed in small intestine, colon, prostate, and human brain tissues, and the cGKII gene maps to chromosome 4q13.1-q21.1. cGKII has been shown to regulate the ion transport system in the intestine. Myristoylation of the penultimate glycine in cGKII appears to be essential for directing cGKII to the membrane, since cGKII is devoid of any hydrophobic transmembrane domains. The translocation of cGKII from the cytosol to the membrane allows it to function properly in regulating intestinal ion transport.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: NP_006250
Immunogen: Synthetic peptide of human PRKG2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Highly concentrated in brain, lung and intestinal mucosa.
Cellular Localization: Cytosol,Nucleus,nuclear membrane,Plasma Membrane,apical plasma membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-prkg2_polyclonal_antibody-32195.html
Manual Link: https://www.elabscience.com/viewpdf-32195-elabscience-E-AB-12751.PDF