ITGA6 Polyclonal AntibodyE-AB-12770
Product Type: Antibody
Descritpion: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine witHuman, Mouseultiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Developmental biology, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_000201
Immunogen: Synthetic peptide of human ITGA6
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
Cellular Localization: Cell membrane. Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-itga6_polyclonal_antibody-32214.html
Manual Link: https://www.elabscience.com/viewpdf-32214-elabscience-E-AB-12770.PDF