Product Type: Antibody
Descritpion: This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.
Research Areas: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_115977
Immunogen: Synthetic peptide of human TRIM63
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 40kDa
Tissue Specificity/Positive Control: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
Cellular Localization: Cytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-trim63_polyclonal_antibody-32235.html
Manual Link: https://www.elabscience.com/viewpdf-32235-elabscience-E-AB-12792.PDF