ARIH2 Polyclonal AntibodyE-AB-12985
Product Type: Antibody
Descritpion: TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
Research Areas: Cell Biology, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: NP_006312
Immunogen: Synthetic peptide of human ARIH2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control: Widely expressed with higher expression in granulocytes.
Cellular Localization: Nucleus. Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-arih2_polyclonal_antibody-32427.html
Manual Link: https://www.elabscience.com/viewpdf-32427-elabscience-E-AB-12985.PDF