Product Type: Antibody
Descritpion: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:200-1:1000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_002902
Immunogen: Synthetic peptide of human UPF1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 124kDa
Tissue Specificity/Positive Control: Ubiquitous.
Cellular Localization: Cytoplasm. Cytoplasm>P-body. Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-upf1_polyclonal_antibody-32442.html
Manual Link: https://www.elabscience.com/viewpdf-32442-elabscience-E-AB-13000.PDF