NES Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Nestin is a type IV intermediate filament protein expressed by neuroepithelial stem cells and which has been proposed to represent a marker for putative islet stem cells. It is a high molecular weight protein with a terminus greater than 500 residues. Nestins are expressed by several types of cells during development, mostly in dividing cells of the Central Nervous System, Peripheral Nervous System and myogenic tissues. It also represents the progenitor population of neural stem cell origin. The role of nestin in dynamic cells, particularly structural organization of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or internexin. Nestin has recently received attention as a marker for detecting newly formed endothelial cells.
Research Areas: Cancer, Cardiovascular, Developmental biology, Neuroscience, Stem cells
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Concentration: 0.2mg/mL
Swissprot: P48681
Gene Accession: NP_006608
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human NES
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: CNS stem cells.
Cellular Localization: Cytoskeleton,intermediate filament,intermediate filament cytoskeleton,Extracellular region or secreted,extracellular matrix,Other locations:cytoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-nes_polyclonal_antibody-32444.html
Manual Link: https://www.elabscience.com/viewpdf-32444-elabscience-E-AB-13002.PDF