PKC gamma Polyclonal AntibodyE-AB-13012
Product Type: Antibody
Descritpion: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14)
Research Areas: Cancer, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: NP_002730
Immunogen: Synthetic peptide of human PRKCG
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 78kDa
Tissue Specificity/Positive Control: Expressed in Purkinje cells of the cerebellar cortex.
Cellular Localization: Cytosol,Nucleus,Plasma Membrane,synaptic membrane,Other locations:cell-cell junction,dendrite,intracellular,perinuclear region of cytoplasm,postsynaptic density
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pkc_gamma_polyclonal_antibody-32454.html
Manual Link: https://www.elabscience.com/viewpdf-32454-elabscience-E-AB-13012.PDF