Product Type: Antibody
Descritpion: Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3’ position. PI 3-kinase p55 (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55 protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55 mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55 have been identified; one of which has a deletion of 36 amino acids at the amino terminus and another which has an insertion of 59 amino acids at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55 interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors.
Research Areas: Signal transduction
Recommended Dilutions: IHC 1:50-1:100
Size: 200 uL
Gene Accession: NP_001107644
Immunogen: Synthetic peptide of human PIK3R3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Cellular Localization: Cytosol,Other locations:phosphatidylinositol 3-kinase complex
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pik3r3_polyclonal_antibody-32460.html
Manual Link: https://www.elabscience.com/viewpdf-32460-elabscience-E-AB-13018.PDF