ASPN Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
Research Areas: Cancer, Signal transduction
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: Q9BXN1
Gene Accession: NP_001180264
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human ASPN
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 43kDa
Tissue Specificity/Positive Control: Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Co-localizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage.
Cellular Localization: Secreted>extracellular space>extracellular matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-aspn_polyclonal_antibody-32487.html
Manual Link: https://www.elabscience.com/viewpdf-32487-elabscience-E-AB-13047.PDF