Product Type: Antibody
Descritpion: This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Research Areas: Cancer, Cardiovascular, Metabolism, Developmental biology, Signal transduction, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001225
Immunogen: Synthetic peptide of human CAV3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 17kDa
Tissue Specificity/Positive Control: Expressed predominantly in muscle.
Cellular Localization: Golgi apparatus membrane. Cell membrane. Membrane>caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-cav3_polyclonal_antibody-32489.html
Manual Link: https://www.elabscience.com/viewpdf-32489-elabscience-E-AB-13049.PDF