BCAS4 Polyclonal AntibodyE-AB-13088
Product Type: Antibody
Descritpion: The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid protein, is found in a region on chromosome 20 that is frequently amplified in human breast cancer. This 20q13 locus amplification is found in 12%–39% of primary breast tumors, which correlates with a 17q23 locus amplification that is found in 20% of primary breast tumors. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, results in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resultant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocular and upper limb anomalies. BCAS4 is normally expressed in thymus, kidney, spleen, placenta and brain. There are three isoforms of BCAS4 which are produced as a result of alternative splicing events.
Research Areas: Cancer
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: NP_001010974
Immunogen: Synthetic peptide of human BCAS4
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Brain, thymus, spleen, kidney and placenta. Overexpressed in most breast cancer cell lines.
Cellular Localization: Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-bcas4_polyclonal_antibody-32528.html
Manual Link: https://www.elabscience.com/viewpdf-32528-elabscience-E-AB-13088.PDF