CBL Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: P22681
Gene Accession: NP_005179
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human CBL
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 100kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-cbl_polyclonal_antibody-32539.html
Manual Link: https://www.elabscience.com/viewpdf-32539-elabscience-E-AB-13099.PDF