Product Type: Antibody
Descritpion: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Cardiovascular, Signal transduction
Recommended Dilutions: IHC 1:100-1:300
Size: 200 uL
Gene Accession: NP_085059
Immunogen: Synthetic peptide of human COL18A1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Present in multiple organs with highest levels in liver, lung and kidney.
Cellular Localization: Secreted, extracellular space, extracellular matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-col18a1_polyclonal_antibody-32653.html
Manual Link: https://www.elabscience.com/viewpdf-32653-elabscience-E-AB-13213.PDF