Product Type: Antibody
Descritpion: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Stem cells
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001420
Immunogen: Synthetic peptide of human EP300
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-p300_polyclonal_antibody-32654.html
Manual Link: https://www.elabscience.com/viewpdf-32654-elabscience-E-AB-13214.PDF