Product Type: Antibody
Descritpion: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1? and IRE1? are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Research Areas: Signal Transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_150296
Immunogen: Synthetic peptide of human ERN2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Endoplasmic reticulum,IRE1-TRAF2-ASK1 complex,Other locations:integral component of membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ern2_polyclonal_antibody-32661.html
Manual Link: https://www.elabscience.com/viewpdf-32661-elabscience-E-AB-13221.PDF