FAT1 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. 
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: Q14517
Gene Accession: NP_005236
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human FAT1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Expressed in many epithelial and some endothelial and smooth muscle cells.
Cellular Localization: Cell membrane. Nucleus. Cytoplasm>perinuclear region.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-fat1_polyclonal_antibody-32677.html
Manual Link: https://www.elabscience.com/viewpdf-32677-elabscience-E-AB-13237.PDF