LE/AF Purified Anti-Mouse CD314 Monoclonal AntibodyE-AB-1350
Product Type: monoclonal antibody for FC
Description: NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, ?/? T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-?, GM-CSF, TNF-?, MIP1? and others) and granzyme release from NK cells.
Resarch Areas: Cancer, Immunology
Size: 500 ug
Clone No: HMG2D
Isotype: Hamster IgG
Formulation: PBS, PH7.2
Purification: Protein G
Conjugation: Low endotoxin/Azide Free
Storage: Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at -20°C or lower. Avoid freeze/thaw cycles.
Product Link: https://www.elabscience.com/p-le_af_purified_anti_mouse_cd314_monoclonal_antibody-39228.html
Manual Link: https://www.elabscience.com/viewpdf-39228-elabscience-E-AB-1350.PDF