Purified Anti-Human CD11a Monoclonal AntibodyE-AB-1407
Product Type: monoclonal antibody for FC
Description: The CD11a (HI111) antibody recognizes the 180-kDa integrin ? chain associated with CD18, the 95-kDa integrin ?2, which form heterodimer glycoprotein called the lymphocyte function antigen-1 (LFA-1, CD11a/CD18). Leukocytes express four CD11/CD18 integrins which include a common ?2 subunit and distinctive ? chains. Besides CD11a/CD18, the other three integrins are known as CD11b/CD18, CD11c/CD18 and CD11d/CD18. LFA-1 is expressed on all leukocytes and is responsible for adhesion between leukocytes during immune response and transmigration of leukocytes across endothelium. The ligands for CD11a/CD18 are intercellular adhesion molecules CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). Patients bearing mutated CD18 genes do not express cell membrane LFA-1, a condition known as leukocyte adhesion deficiency 1 (LAD-1).
Resarch Areas: Cancer, Immunology, Signal transduction, Stem cells
Size: 100 ug
Clone No: HI111
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used from 20 µL to 5 µL per 100 µL of peripheral blood. Please check your vial). Since applications vary, the appropriate dilutions must be determined for individual use.
Isotype: Mouse IgG1
Formulation: PBS with 0.09% NaN3, 0.2% BSA, PH7.2
Storage: Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at -20°C or lower. Avoid freeze/thaw cycles.
Product Link: https://www.elabscience.com/p-purified_anti_human_cd11a_monoclonal_antibody-38958.html
Manual Link: https://www.elabscience.com/viewpdf-38958-elabscience-E-AB-1407.PDF