ALKBH2 Polyclonal AntibodyE-AB-14464
Product Type: Antibody
Descritpion: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Research Areas: Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC070489
Immunogen: Recombinant protein of human ALKBH2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 29kDa
Tissue Specificity/Positive Control: Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
Cellular Localization: Nucleus. Detected in replication foci during S-phase.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-alkbh2_polyclonal_antibody-33892.html
Manual Link: https://www.elabscience.com/viewpdf-33892-elabscience-E-AB-14464.PDF