Product Type: Antibody
Descritpion: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: BC022530
Immunogen: Recombinant protein of human ACVR1C
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.