ACVR2A Polyclonal AntibodyE-AB-14487
Product Type: Antibody
Descritpion: This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Research Areas: Cancer, Metabolism, Signal transduction, Stem cells
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC069707
Immunogen: Recombinant protein of human ACVR2A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control:
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-acvr2a_polyclonal_antibody-33915.html
Manual Link: https://www.elabscience.com/viewpdf-33915-elabscience-E-AB-14487.PDF