Product Type: Antibody
Descritpion: The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes.
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: BC117155
Immunogen: Recombinant protein of human ACOT8
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Detected in a T-cell line (at protein level). Ubiquitous.
Cellular Localization: Peroxisome.
Storage: Store at -20C. Avoid freeze / thaw cycles.