ALS2 Polyclonal AntibodyE-AB-14551
Product Type: Antibody
Descritpion: The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC029174
Immunogen: Recombinant protein of human ALS2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Cytoskeleton,centrosome,Cytosol,Endosome,early endosome,Other locations:axon,dendrite,dendritic spine,growth cone,intracellular membrane-bounded organelle,lamellipodium,membrane,neuronal cell body,postsynaptic density,protein complex,ruffle,vesicle
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-als2_polyclonal_antibody-33979.html
Manual Link: https://www.elabscience.com/viewpdf-33979-elabscience-E-AB-14551.PDF