Product Type: Antibody
Descritpion: This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Metabolism, Neuroscience
Recommended Dilutions: WB 1:200-1:1000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC008302
Immunogen: Recombinant protein of human STRADB
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 47/31kDa
Tissue Specificity/Positive Control: Highly expressed in heart, skeletal muscle, testis, liver and colon.
Cellular Localization: Nucleus. Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.