Product Type: Antibody
Descritpion: Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC012321
Immunogen: Recombinant protein of human ARC
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 45kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm>cytoskeleton. Endosome. Cytoplasmic vesicle>secretory vesicle>acrosome. Cell junction>synapse>postsynaptic cell membrane>postsynaptic density. Cell projection>dendrite. Cell projection>dendritic spine. Cell junction>synapse. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.