Product Type: Antibody
Descritpion: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Research Areas: Cell Biology, Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC002854
Immunogen: Recombinant protein of human USP2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
Cellular Localization: Nucleus and Cytoplasm. Cytoplasm>perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.