MARK1 Polyclonal AntibodyE-AB-14680
Product Type: Antibody
Descritpion: MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
Research Areas: Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC113869
Immunogen: Recombinant protein of human MARK1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 89kDa
Tissue Specificity/Positive Control: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Cellular Localization: Cytoplasm>cytoskeleton. Appears to localize to an intracellular network.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-mark1_polyclonal_antibody-34108.html
Manual Link: https://www.elabscience.com/viewpdf-34108-elabscience-E-AB-14680.PDF