PIM1 Polyclonal AntibodyE-AB-14694
Product Type: Antibody
Descritpion: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC020224
Immunogen: Recombinant protein of human PIM1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
Cellular Localization: Cytoplasm. Nucleus and Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pim1_polyclonal_antibody-34122.html
Manual Link: https://www.elabscience.com/viewpdf-34122-elabscience-E-AB-14694.PDF