Product Type: Antibody
Descritpion: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:100-1:300
Size: 200 uL
Gene Accession: BC021116
Immunogen: Recombinant protein of human HK2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 102kDa
Tissue Specificity/Positive Control: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Cellular Localization: Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
Storage: Store at -20C. Avoid freeze / thaw cycles.