Product Type: Antibody
Descritpion: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC008730
Immunogen: Recombinant protein of human HK1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.
Cellular Localization: Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
Storage: Store at -20C. Avoid freeze / thaw cycles.