FAK Polyclonal AntibodyE-AB-14709
Product Type: Antibody
Descritpion: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Research Areas: Cancer, Cardiovascular, Signal transduction
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: BC028733
Immunogen: Recombinant protein of human PTK2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 119kDa
Tissue Specificity/Positive Control: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.
Cellular Localization: Cell junction>focal adhesion. Cell membrane. Constituent of focal adhesions.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-fak_polyclonal_antibody-34137.html
Manual Link: https://www.elabscience.com/viewpdf-34137-elabscience-E-AB-14709.PDF