Product Type: Antibody
Descritpion: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Research Areas: Cancer, Cardiovascular, Immunology, Stem cells
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC015969
Immunogen: Recombinant protein of human ICAM1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control:
Cellular Localization: Membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.