Product Type: Antibody
Descritpion: Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
Research Areas: Epigenetics and Nuclear Signaling, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC016139
Immunogen: Recombinant protein of human CBY1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Cellular Localization: Nucleus speckle. Golgi apparatus, trans-Golgi network. Nuclear, in a punctate manner. Also found in the trans-Golgi.
Storage: Store at -20C. Avoid freeze / thaw cycles.