Product Type: Antibody
Descritpion: VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300
Size: 200 uL
Gene Accession: BC001234
Immunogen: Recombinant protein of human VWA5A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 86kDa
Tissue Specificity/Positive Control: Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
Cellular Localization: Nucleus
Storage: Store at -20C. Avoid freeze / thaw cycles.