Product Type: Antibody
Descritpion: This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Research Areas: Cardiovascular, Immunology, Microbiology
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC040955
Immunogen: Recombinant protein of human BPI
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Restricted to cells of the myeloid series.
Cellular Localization: Secreted. Cytoplasmic granule membrane. Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Storage: Store at -20C. Avoid freeze / thaw cycles.