TSC2 Polyclonal AntibodyE-AB-15921
Product Type: Antibody
Descritpion: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_000539
Immunogen: Synthetic peptide of human TSC2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Cellular Localization: Cytoplasm. Membrane. At steady state found in association with membranes.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-tsc2_polyclonal_antibody-35319.html
Manual Link: https://www.elabscience.com/viewpdf-35319-elabscience-E-AB-15921.PDF