Product Type: Antibody
Descritpion: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Research Areas: Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_055387
Immunogen: Synthetic peptide of human LATS2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
Cellular Localization: Cytoplasm>cytoskeleton>centrosome. Cytoplasm. Cytoplasm>cytoskeleton>spindle pole. Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
Storage: Store at -20C. Avoid freeze / thaw cycles.