BCAS3 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ERå (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ERå transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.
Research Areas: Cancer, Stem cells
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Concentration: 0.8mg/mL
Swissprot: Q9H6U6
Gene Accession: NP_001092902
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human BCAS3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-bcas3_polyclonal_antibody-35361.html
Manual Link: https://www.elabscience.com/viewpdf-35361-elabscience-E-AB-15963.PDF