ACO1 Polyclonal AntibodyE-AB-16129
Product Type: Antibody
Descritpion: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: WB 1:1000-1:5000
Size: 200 uL
Gene Accession: NP_002188
Immunogen: Synthetic peptide of human ACO1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 98kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-aco1_polyclonal_antibody-35526.html
Manual Link: https://www.elabscience.com/viewpdf-35526-elabscience-E-AB-16129.PDF