Product Type: Antibody
Descritpion: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
Research Areas: Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_055599
Immunogen: Synthetic peptide of human ARHGEF11
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 168kDa
Tissue Specificity/Positive Control: Ubiquitously expressed.
Cellular Localization: Cytoplasm. Membrane. Translocated to the membrane upon stimulation.
Storage: Store at -20C. Avoid freeze / thaw cycles.