Product Type: Antibody
Descritpion: The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
Research Areas: Cancer, Immunology
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_619649
Immunogen: Synthetic peptide of human NDNL2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 34kDa
Tissue Specificity/Positive Control: Ubiquitous.1 Publication
Cellular Localization: Cytoplasmic and Nuclear
Storage: Store at -20C. Avoid freeze / thaw cycles.