Product Type: Antibody
Descritpion: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.
Research Areas: Cancer, Cell Biology, Cardiovascular, Metabolism
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_004521
Immunogen: Synthetic peptide of human MMP2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Cellular Localization: Secreted>extracellular space>extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Storage: Store at -20C. Avoid freeze / thaw cycles.