ARL3 Polyclonal AntibodyE-AB-16263
Product Type: Antibody
Descritpion: ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: NP_004302
Immunogen: Synthetic peptide of human ARL3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 20kDa
Tissue Specificity/Positive Control: Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level).
Cellular Localization: Golgi apparatus membrane. Cytoplasm>cytoskeleton>spindle. Nucleus. Cytoplasm>cytoskeleton>centrosome. Cytoplasm. Cell projection>cilium. Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-arl3_polyclonal_antibody-35658.html
Manual Link: https://www.elabscience.com/viewpdf-35658-elabscience-E-AB-16263.PDF