EIF4G1 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. 
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Concentration: 0.5mg/mL
Swissprot: Q04637
Gene Accession: NP_004944
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human EIF4G1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 175kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytosol,Nucleus,Other locations:cytoplasm,eukaryotic translation initiation factor 4F complex,membrane,polysome
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-eif4g1_polyclonal_antibody-35796.html
Manual Link: https://www.elabscience.com/viewpdf-35796-elabscience-E-AB-16401.PDF