Product Type: Antibody
Descritpion: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
Research Areas: Cancer, Metabolism, Signal transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_055761
Immunogen: Synthetic peptide of human SPAST
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord.1 Publication
Cellular Localization: Cytoplasm, Cytoskeleton, Endoplasmic reticulum,
Endosome, Membrane, Microtubule, Nucleus
Storage: Store at -20C. Avoid freeze / thaw cycles.