Product Type: Antibody
Descritpion: The Anp32 family consists of 32 evolutionarily-conserved proteins and is included within the superfamily of leucine-rich repeat (LRR) proteins. Leucine-rich acidic nuclear protein-like (LANPL), also called ANP32E or Cpd1, is a member of the Anp32 family. LANPL is located in the cytoplasm of peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. It has also been detected in the nucleus, cytoplasm and membrane of multiple brain regions. Upon phosphorylation, LANPL colocalizes and inhibits protein phosphatase 2A (PP2A), but does not inhibit PP1. LANPL modulates cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development and cerebellar morphogenesis.
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_112182
Immunogen: Synthetic peptide of human ANP32E
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 31kDa
Tissue Specificity/Positive Control: Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
Cellular Localization: Cytoplasm. Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.