LOXL3 Polyclonal AntibodyE-AB-16575
Product Type: Antibody
Descritpion: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to eacHuman, Mouseember of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
Research Areas: Signal transduction
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_115992
Immunogen: Synthetic peptide of human LOXL3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed in many tissues, the highest levels among the tissues studied being seen in the placenta, heart, ovary, testis, small intestine and spleen.
Cellular Localization: Secreted>extracellular space.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-loxl3_polyclonal_antibody-35970.html
Manual Link: https://www.elabscience.com/viewpdf-35970-elabscience-E-AB-16575.PDF